The mechanism of damage-induced mutations in Escherichia coli
Year: 2015
Type: dissertation
Abstract: The integrity of the genome is fundamental to the survival of an organism. Escherichia coli possesses an inducible, physiological reaction to DNA damage. The SOS response, as the phenomena had come to be known, involves an upregulation of otherwise repressed genes that are engaged in DNA repair, replication and recombination. An accompanying consequence is the large increase in mutations caused by translesion DNA synthesis (TLS). TLS requires DNA polymerase V and RecA protein.
Author: Schlacher, Katharina (author)
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2245911874