Lack of appropriate controls leads to mistaking absence seizures for post-traumatic epilepsy
Year: 2015
Type: preprint
Abstract: Here we provide a thorough discussion of a rebuttal by D'Ambrosio et al to a study conducted by Rodgers et al. (Rodgers KM, Dudek FE, Barth DS (2015) Progressive, Seizure-Like, Spike- Wave Discharges Are Common in Both Injured and Uninjured Sprague-Dawley Rats: Implications for the Fluid Percussion Injury Model of Post-Traumatic Epilepsy. J Neurosci. 35(24):9194-204. doi: 10.1523/JNEUROSCI.0919-15.2015.) to investigate focal seizures and acquired epileptogenesis induced by head injury in the rat. This manuscript serves as supplementary document for our letter to the Editor to appear in the Journal of Neuroscience. We find the rebuttal is flawed on all points, particularly concerning use of proper controls, experimental methods, analytical methods, and epilepsy diagnostic criteria, leading to mistaking absence seizures for post-traumatic epilepsy.
Source: arXiv (Cornell University)
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2246498767