IGF-1 and IGFBP-3 Levels in Individuals with Varied Kidney Function and the Relation to Dietary Protein Intake
Year: 2009
Type: article
Abstract: PURPOSE: The purpose of the study was to find if IGF-1 and IGFBP-3 levels were altered with varied kidney function in a large sample of the U.S. population.Then, to exam whether IGF-1 and IGFBP-3 levels were altered with varied protein intake in all levels of kidney function.METHODS: Participants included a subsample of 6058 participants from the National Health and Nutrition Examination Survey III (NHANES III, 1988-1994), a nationally representative sample of apparently healthy, non-institutionalized participants ages > 20 years.Statistical analysis was conducted utilizing Statistical Analysis Systems (SAS, version 9.1, Cary, NC) and SUDDAN (Release 5.50, Research Triangle Park, NC) to account for the complex survey sampling.General differences in IGF protein concentrations across subjects categorized by demographic and body mass index (BMI) categories were investigated.Analysis of variance (ANOVA) for continuous variables and Wald's Chi Square test for categorical data were utilized to compare IGF protein concentrations across classification groups.Kidney function was assessed using the simplified Modification of Diet in Renal Disease (MDRD) formula with standardized serum creatinine to estimate glomerular filtration rate (GFR).Multiple backwards stepwise regressions were employed to test the effects of multiple variables in predicting IGF protein concentrations and kidney function.RESULTS: Age and sex were significant covariates for IGF-1, IGFBP-3 concentrations, and IGF-1/IGFBP-3 molar ratio.IGF-I concentrations were related to race/ethnicity with the lowest wonderful friend, roommate, and colleague Jessica Sargood.She always encouraged me to work hard and have fun.Her inspiration and compassion made me the dietitian I am today.I want to thank my friends Erin Tucker, Robin Larkin, Julia Bancroft, Laura Grothaus and Jackie Fritch for all their support and
Author: Megan Kh Sankey
Institution: Bowling Green State University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2246835629