Evaluation of Haemostatic Abnormalities among Sudanese Patients with Haematologic and Solid Malignancy
Year: 2014
Type: article
Study design: Observational Study
Abstract: Cancer is a broad group of various diseases, all involving unregulated cell growth. Both experimental and clinical studies have evidenced an association between cancer and haemostasis. This study aimed to evaluate the haemostatic property among cancer patients in Sudan by determining D-dimer level, activated partial thromboplastin time (APTT), prothrombin time (PT) and platelets count. Following informed consent, one hundred and twenty subjects were enrolled in this cross-sectional study: Sixty patients with haematologic or solid malignancies (pathologically confirmed) attending Alzara hospital; and age and sex matched sixty normal subjects as controls. D-Dimer was measured using i-CHROMATM system, APTT and PT were measured using coagulometer (Sysmex CA 50), and Platelets count was measured by automated cell counter (Sysmex Kx21). The results of the cancer patients were as follows: mean D-Dimer level was 2196.32±2110.95 ng/ml, mean APTT was 35.7±6.6 seconds, mean PT was 13.7±1.3 seconds and mean platelets count was 249.6±142.3 X109/L; while for the control: mean D-Dimer level was 213.65±103.57ng/ml, mean APTT was 29.6±2.2 seconds, mean PT was 12.2±0.8 seconds and mean platelets count was 279.7±77.9 X109/L. Mean D-Dimer level was significantly higher among cancer patients than the controls (p value (0.000). mean APTT and PT were also higher among cancer patients than the controls (p value 0.000, for both parameters). There was a significant association between the D-Dimer levels and the plasma clotting times (APTT and PT). In conclusion, our study confirms the hypercoagulable state among various types of malignancies in Sudan, which has been determined by elevated D-Dimer levels.
Authors: Amr O. A. Omer, Mahdi H. A. Abdalla
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2246976938