Work

Role of Chemokines in Regulating Oligodendrocyte Development, Astrogliosis, and Demyelinating Diseases

Year: 2010

Type: article

Abstract: Chapter 1 Background and Introduction I. Cellular composition of the nervous system a.Astrocytes role in central nervous system function b.Microglia: the primary immune defense in the CNS c. Oligodendrocyte development and unique features II.Inflammatory reaction and pathology in the CNS a. Cytokines and their responsibility in inflammatory response b.Chemokines and cytokines in development and disease c.CXCR2 function and role in oligodendrocyte development and pathology III.Demyelinating disorders and Multiple Sclerosis a. Current MS treatments modulate symptoms and inflammation b.Experimental models of Multiple Sclerosis c. Remyelination success and failure in MS IV.Primary hypothsis of this dissertation Chapter 2 Inhibition of CXCR2 signaling promotes recovery in models of Multiple Sclerosis I. Abstract II.Introduction III.Materials and methods IV. Results V. DiscussionChapter 3 Regulation of astrogliosis by the chemokine CXCL1 I.

Source: OhioLink ETD Center (Ohio Library and Information Network)

Author: Amber Kerstetter-Fogle

Institution: Case Western Reserve University

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Case Western Reserve University, Myelin Repair Foundation, National Institutes of Health

OpenAlex ID: W2249602268

FWCI:

Cites: 252

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Related to: 10