Differential expression of recent gene duplicates in developmental tissues of Arabidopsis thaliana
Year: 2009
Type: article
Abstract: Gene duplication can lead to increased morphological complexity by giving rise to new genes and gene functions.The classic Ohno model predicts new gene duplicates will be functionally redundant.However, this model does not address functional divergence due to differential expression.To test this possibility, the developmental expression patterns of 18 pairs of unlinked recent duplicates in Arabidopsis thaliana were characterized.These duplicates have a K s less than 5%, are less than 2 my old, and are specific to the A. thaliana lineage.The coding regions of these duplicates are generally complete, although they share only an average 616 bp of upstream regulatory sequence.We found that the majority of duplicate loci have non-redundant expression patterns, suggesting functional divergence occurs soon after duplication for unlinked duplicates.Furthermore, comparison of expression data from this study to online databases suggests these databases cannot reliably differentiate expression patterns among recent duplicate genes.v ACKNOWLEDGMENTS First and foremost, I want to thank my advisor, Dr.Richard Moore, for guiding me so kindly and expertly through the past three and a half years.Not only is Rich a great mentor, but also a great friend.His office door is always open for advice.His home is open as well.Rich and his wife have often generously welcomed the members of the lab into their home, and I have many fond memories of these gatherings.From card games and Chinese New Year meals, to The Moore Lab Quote Board we have had a lot of good times.I am truly thankful for Rich's guidance and care.Rich has fostered a fun, yet hardworking research environment.The Moore Lab is often working the hardest and having the most fun in the process.I also want to acknowledge specific members of the Moore Lab for their support, hard work, and kindness.First, I thank Nicholas Harberson, who played a big role in obtaining and expertly organizing expression data from online databases.Not only did his work play a big role in my thesis, but his enthusiasm and work ethic were encouraging when I was feeling frustrated
Author: Sarah M. Owens
Institution: Miami University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2249743452