Reactive Oxygen Species in Proliferative Signaling
Year: 2000
Type: book-chapter
Abstract: The traditional view of reactive oxygen species (ROS), such as H2O2 and superoxide (O2 −), as toxic byproducts of aerobic metabolism, and their use as antimicrobial agents by the immune system, might make the notion that ROS can act as positive regulators of cell proliferation somewhat counterintuitive. Nonetheless, evidence has accumulated over the past 10 years that strongly supports ROS regulation of a variety of cellular processes, including proliferation. The picture that has emerged indicates that ROS are previously unappreciated components of established regulatory pathways. More specifically, it appears that ROS act as messengers in signal transduction pathways (1).
Source: Humana Press eBooks
Authors: Toren Finkel, Daniel M. Sullivan
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W2251310247