Work

RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications

Year: 2015

Type: review

Abstract: Accurate genetic information transfer is essential for life. As a key enzyme involved in the first step of gene expression, RNA polymerase II (Pol II) must maintain high transcriptional fidelity while it reads along DNA template and synthesizes RNA transcript in a stepwise manner during transcription elongation. DNA lesions or modifications may lead to significant changes in transcriptional fidelity or transcription elongation dynamics. In this review, we will summarize recent progress toward understanding the molecular basis of RNA Pol II transcriptional fidelity control and impacts of DNA lesions and modifications on Pol II transcription elongation.

Source: Critical Reviews in Biochemistry and Molecular Biology

DOI: 10.3109/10409238.2015.1087960

Authors: Liang Xu, Wei Wang, Jenny Chong, Ji Hyun Shin, Jun Xu, Dong Wang

Institution: University of California San Diego

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Awards: G1409347209, Molecular Mechanisms for DNA Damage Processing by Transcription Machinery