Controlling the Burst Effect of a Drug by Introducing Starch in the Structure of Magnetic Polyurethane Microspheres Containing Super Paramagnetic Iron Oxide Nanoparticles
Year: 2010
Type: article
Abstract: The aim of this research is to prepare superparamagnetic polyurethane microspheres using SPIONs.Theophylline was used as a drug and the various stoichiometric ratios of isocyanate/polyol were studied to assess their application as a targeting delivery system.Magnetic polyurethane microspheres containing superparamagnetic iron oxide nanoparticles loaded with theophylline were prepared by the water in oil in water emulsion technique.The ratio of hexamethylenediisocyanate and polyol ("-polycaprolactone and starch) was modi ed and the release of theophylline was determined for a period of 20 days.These microspheres were characterized by TEM, SEM, FTIR and magnetometry.The microscopy images show the morphological shape of the superparamagnetic microspheres with an average size of 5 m.The FTIR and the magnetometry con rmed the presence of superparamagnetic nanoparticles in the microspheres.The release of theophylline was studied and dosed by UV spectrophotometer.With the use of PCL with a low molecular weight or in the presence of starch in the structure of polyurethane, the burst eect of drug is decreased.Finally, a SEM study showed an important degradation of the microspheres after the release process.The use of starch as a polyol caused signi cant improvement in burst eect of the superparamagnetic polyurethane microspheres.
Source: ORBi UMONS
Authors: Morteza Mahmoudi, Sophie Laurent
Institutions: University of Tehran, Institut Henri Poincaré
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2252690534