Year: 2016
Type: review
Abstract: Stem cell therapy provides immense hope for regenerating the pathological heart, yet has been marred by issues surrounding the effectiveness, unclear mechanisms, and survival of the donated cell population in the ischemic myocardial milieu. Poor survival and engraftment coupled to inadequate cardiac commitment of the adoptively transferred stem cells compromises the improvement in cardiac function. Various alternative approaches to enhance the efficacy of stem cell therapies and to overcome issues with cell therapy have been used with varied success. Cell-free components, such as exosomes enriched in proteins, messenger RNAs, and miRs characteristic of parental stem cells, represent a potential approach for treating cardiovascular diseases. Recently, exosomes from different kinds of stem cells have been effectively used to promote cardiac function in the pathological heart. The aim of this review is to summarize current research efforts on stem cell exosomes, including their potential benefits and limitations to develop a potentially viable therapy for cardiovascular problems.
Source: Circulation Research
Authors: Raj Kishore, Mohsin Khan
Institution: Temple University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: G1187687215, Pluripotent cell-derived exosomes as mediators of myocardial regeneration, Cardiovascular Regenerative Medicine, G1882761228, Therapeutic Angiogenesis in Vascular Medicine IV, THERAPEUTIC ANGIOGENESIS IN VASCULAR MEDICINE II, G2989483998, G4713112887, Effect of chronic alcohol on ischemic injury and endothelial cells, Circular RNAs as novel mediators of cardiac repair, G6379962146, G7675838419
OpenAlex ID: W2252804625