Work

Vascular diseases await translation of blood vessels engineered from stem cells

Year: 2015

Type: article

Abstract: The discovery of human induced pluripotent stem cells (hiPSCs) might pave the way toward a long-sought solution for obtaining sufficient numbers of autologous cells for tissue engineering. Several methods exist for generating endothelial cells or perivascular cells from hiPSCs in vitro for use in the building of vascular tissue. We discuss current developments in the generation of vascular progenitor cells from hiPSCs and the assessment of their functional capacity in vivo, opportunities and challenges for the clinical translation of engineered vascular tissue, and modeling of vascular diseases using hiPSC-derived vascular progenitor cells.

Source: Science Translational Medicine

DOI: 10.1126/scitranslmed.aaa1805

Authors: Rekha Samuel, Dan G. Duda, Dai Fukumura, Rakesh K. Jain

Institutions: Harvard University, Christian Medical College, Vellore, Massachusetts General Hospital

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute