MRSA: The Resistance Is Getting More Difficult
Year: 2020
Type: article
Abstract: � � ethicillin-resistantStaphylococcus aureus� � � (MRSA)�haslongknownasanimportant� � � multidrugresistantbacterialpathogenthat� playsathreateningroleamongstnosocomialinfection� orpatientswhohavestayedinlong-termhealthcare� facilities.�InfectionduetoMRSAcausesasubstantial� healthcareburdenbecauseofalongerdurationof� hospitalstay,�alimitationoftreatmentoptionsanda� difficultyinmanaginginfectioncomplications,�andthus� resultinginhighermorbidityandmortalityrates.� PrevalenceofMRSAinfectionvariesgreatlyaccording� togeographicregionsfromlessthan�5%�inseveral� Europeancountriestoover�50%�inmanyAsiancoun- tries.�Duringthelastdecade,�anincreaseofcommunity- acquiredinfectionduetoMRSAhasraisedmore� attentionduetoitsrapidspreadandtheseverityofthe� diseaseitmaycause.�Notsurprisingly,�ariseofinfec- tionrateduetoMRSA,�whichisresistanttoallbeta- lactamagents,�leadstoaheavyuseofglycopeptides,� theantimicrobialagentsofchoice�(e.g.�vancomycin).� MRSAstrainswithdecreasedsusceptibilitytoglycopep- tides,�asaresult,�havebeenemergedrecently,�andare� impendingfortheirspreadunlessrigorousinfection� controlisimplemented.�Newerantimicrobialagentswith� activityagainstMRSAarecurrentlyavailableinsome� limitedcountries,�butremaintobefurtherevaluatedfor� clinicaluse.�Thisreviewwilldiscussvariousaspectsof� MRSAincludingbackground�(structuralandmolecular� characteristics),�laboratorydetection,�susceptibilitiesto� antimicrobialagents,�prevalenceincludinglocaldataand� controlmeasures.� �of MRSA�� � Morethanadecadeafterbeingdiscoveredby�
Author: Pattarachai Kiratisin
Institutions: Siriraj Hospital, Mahidol University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2254406498