Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine
Year: 2015
Type: article
Abstract: A bone imaging toolkit of 21 fluorescent probes with variable spectroscopic properties, bone mineral binding affinities, and antiprenylation activities has been created, including a novel linking strategy. The linking chemistry allows attachment of a diverse selection of dyes fluorescent in the visible to near-infrared range to any of the three clinically important heterocyclic bisphosphonate bone drugs (risedronate, zoledronate, and minodronate or their analogues). The resultant suite of conjugates offers multiple options to "mix and match" parent drug structure, fluorescence emission wavelength, relative bone affinity, and presence or absence of antiprenylation activity, for bone-related imaging applications.
Source: Bioconjugate Chemistry
Language: English
Subfield: Spectroscopy
Field: Chemistry
Domain: Physical Sciences
Open Access status: green
Funders: University of Southern California, National Institute for Health and Care Research, National Institutes of Health, National Institute on Deafness and Other Communication Disorders, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute of Dental and Craniofacial Research
Awards: Drug-eluting Stapes Prosthesis for the Prevention of Sensorineural Hearing Loss, G2800880377, Competitive Equilibrium-based Displacement of Bisphosphonates as Novel Therapeutic Approach for BRONJ, Competitive Equilibrium-based Displacement of Bisphosphonates as Novel Therapeutic Approach for BRONJ, G7352502785, Novel Bisphosphonate 18F-PET and PET/optical Dual Modality Probes for Rheumatoid Arthritis Imaging, Molecular and cellular mechanism of ONJ related to osteoclast inhibition
OpenAlex ID: W2254661746