Work

A model qualification method for mechanistic physiological QSP models to support model‐informed drug development

Year: 2016

Type: article

Abstract: Mechanistic physiological modeling is a scientific method that combines available data with scientific knowledge and engineering approaches to facilitate better understanding of biological systems, improve decision-making, reduce risk, and increase efficiency in drug discovery and development. It is a type of quantitative systems pharmacology (QSP) approach that places drug-specific properties in the context of disease biology. This tutorial provides a broadly applicable model qualification method (MQM) to ensure that mechanistic physiological models are fit for their intended purposes.

Source: CPT Pharmacometrics & Systems Pharmacology

DOI: 10.1002/psp4.12056

Author: CM Friedrich

Institution: Rosa (United States)

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $4,140