Patterns and Correlates of Baseline Thiazide-Type Diuretic Prescription in the Systolic Blood Pressure Intervention Trial
Year: 2016
Type: article
Abstract: Thiazides and thiazide-type diuretics are recommended as first-line agents for the treatment of hypertension, but contemporary information on their use in clinical practice is lacking. We examined patterns and correlates of thiazide prescription in a cross-sectional analysis of baseline data from participants enrolled in the Systolic Blood Pressure Intervention Trial (SPRINT). We examined baseline prescription of thiazides in 7582 participants receiving at least 1 antihypertensive medication by subgroup, and used log-binomial regression to calculate adjusted prevalence ratios for thiazide prescription (versus no thiazide). Forty-three percent of all participants were prescribed a thiazide at baseline, but among participants prescribed a single agent, the proportion was only 16%. The prevalence of thiazide prescription differed significantly by demographic factors, with younger participants, women, and blacks all having higher adjusted prevalence of thiazide prescription than other corresponding subgroups. Participants in the lowest category of kidney function (estimated glomerular filtration rate <30 mL/min per 1.73 m2) were half as likely to be prescribed a thiazide as participants with preserved kidney function. In conclusion, among persons with hypertension and heightened cardiovascular risk, we found that thiazide prescription varied significantly by demographics and kidney disease status, despite limited evidence about relative differences in effectiveness.
Source: Hypertension
Authors: Tara I. Chang, Gregory Evans, Alfred K. Cheung, William C. Cushman, Matthew J. Diamond, Jamie P. Dwyer, Yonghong Huan, Dalane Kitzman, John B. Kostis, Suzanne Oparil, Anjay Rastogi, Christianne L. Roumie, Rukmani Sahay, Randall S. Stafford, Addison A. Taylor, Jackson T. Wright, Glenn M. Chertow
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Vanderbilt University, University of Pennsylvania, George Washington University, Tulane University, University of Texas Southwestern Medical Center, University of Pittsburgh, Case Western Reserve University, National Institutes of Health, University of Illinois at Urbana-Champaign, University of California, Davis, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: G1037376802, Stanford Center for Clinical and Translational Education and Research (SCCTER)UL1, G1182793083, G1201304535, G1271685901, G1294028474, G130883262, G1346455397, G1452718737, G1516365345, G1534123016, G153936304, G1575401839, G1638468373, G1815451664, Together: Transforming and Translating Discovery to Improve Health, G2280939255, The Ohio State University Center for Clinical and Translational Science (UL1), G2499961, G256492535, Tufts Clinical and Translational Research Institute, G3042542605, G3340927746, G3345260134, G3370453791, G3604805317, G3658248675, Translational Research in Hypertension and Renal Biology, UC Davis Clinical and Translational Science Center, G3759862710, Clinical and Translational Science Institute at Children's National, UF Clinical and Translational Science Award, G4425699080, G49760422, G5044917027, G5068655555, G522538789, G530069377, G5473830807, G5500374692, G5679716143, G576625284, G5831220822, Tufts Clinical and Translation Science Institute (UL1), G5971433106, G644558944, G6760263438, G6964432450, G7041822434, G715451306, G728281721, G742032275, G7638611195, G7738083902, The Vanderbilt Institute for Clinical and Translational Research (VICTR), G7798204357, G8004166952, G8095131, G847355820, G8723760441, G884570035
OpenAlex ID: W2255642269