Ethanol-HIF-1 alpha axis in inflammatory gene expression in liver cells
Year: 2012
Type: dissertation
Abstract: Chronic alcohol consumption leads to liver inflammation and cirrhosis. Portal hypertension and its complications contribute to mortality in patients with cirrhosis. Concomitant to inflammation and cirrhosis of the liver, alcoholic liver disease patients have increased levels of cytokines and chemokines. Ethanol-induced liver injury has also been shown to be associated with an increased presence of inflammatory cells, e.g. Kupffer cells, in the liver. Further, oxidative stress has been implicated in alcohol-induced inflammation and liver injury. However, relatively less is known about the molecular mechanisms involved in ethanol-induced inflammatory gene expression in liver sinusoidal endothelial cells (LSEC) and Kupffer cells (KC).
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2255790058