Work

IC‐02‐02: Distinct [18F]AV1451 retention patterns in clinical variants of Alzheimer's disease

Year: 2015

Type: article

Abstract: To describe preliminary findings applying the putative tau PET ligand [F]AV1451 (formerly named T807) in clinical variants of Alzheimer's disease (AD) and to compare the regional specificity of [F]AV1451 to that of [C]PIB (measure of amyloid pathology) and [F]FDG (glucose metabolism) PET. PET scans were performed in 5 posterior cortical atrophy (PCA), 4 logopenic variant primary progressive aphasia (lvPPA), 1 early-onset AD and 2 (memory-predominant) late-onset AD patients (all PIB+) and in 19 cognitively normal controls (Table 1). We created SUVr images for [F]AV1451 (80-100 minutes, gray matter cerebellum as reference region) and [F]FDG (30-60 minutes, pons-normalized), and DVR images for [C]PIB (0-90 minutes, gray matter cerebellum as reference region). We visually assessed [F]AV1451, [C]PIB and [F]FDG uptake patterns in 3 distinct AD variants, and performed voxel-wise contrasts (in SPM) between PCA patients and controls. Figure 1 shows asymmetric [F]AV1451 uptake in parietal, temporal and frontal regions (left>right) in a patient with lvPPA, a classical temporoparietal pattern in a patient with memory-predominant AD, and mainly occipitotemporal and occipitoparietal involvement in a PCA patient. [F]AV1451 and [F]FDG appeared strikingly as mirror images, with regions of high [F]AV1451 uptake corresponding to low [F]FDG uptake and vice versa, while [C]PIB binding was observed throughout the association neocortex. Voxelwise contrasts with [F]AV1451 and [F]FDG showed that PCA patients significantly differed from controls in clinically affected posterior brain regions, while [C]PIB binding was greater in both posterior regions and in clinically less affected anterior regions (Figure 2).

Source: Alzheimer s & Dementia

DOI: 10.1016/j.jalz.2015.06.008

Authors: Rik Ossenkoppele, Daniel Schonhaut, Suzanne Baker, Andreas Lazaris, Nagehan Ayakta, Averill Cantwell, Sam Lockhart, Jacob W. Vogel, Henry Schwimmer, Michael Schöll, Maria Luisa Gorno Tempini, Bruce L. Miller, William J. Jagust, Gil D. Rabinovici

Institutions: University of California, San Francisco, Amsterdam UMC Location Vrije Universiteit Amsterdam, University of California, Berkeley

Language: English

Topic: Dementia and Cognitive Impairment Research

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2255989048

FWCI: 0.811

Cites:

Cited by: 3

Related to: 10