A Transient Translaminar GABAergic Interneuron Circuit Connects Thalamocortical Recipient Layers in Neonatal Somatosensory Cortex
Year: 2016
Type: article
Abstract: GABAergic activity is thought to influence developing neocortical sensory circuits. Yet the late postnatal maturation of local layer (L)4 circuits suggests alternate sources of GABAergic control in nascent thalamocortical networks. We show that a population of L5b, somatostatin (SST)-positive interneuron receives early thalamic synaptic input and, using laser-scanning photostimulation, identify an early transient circuit between these cells and L4 spiny stellates (SSNs) that disappears by the end of the L4 critical period. Sensory perturbation disrupts the transition to a local GABAergic circuit, suggesting a link between translaminar and local control of SSNs. Conditional silencing of SST+ interneurons or conversely biasing the circuit toward local inhibition by overexpression of neuregulin-1 type 1 results in an absence of early L5b GABAergic input in mutants and delayed thalamic innervation of SSNs. These data identify a role for L5b SST+ interneurons in the control of SSNs in the early postnatal neocortex.
Source: Neuron
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,469
Awards: Development of thalamocortial connections in mouse barrel cortex: Role of subplate neurons., Zika: Cellular mechanisms of microcephaly due to Zika virus infection in mice, The role of activity in remodelling area specific neocortical circuits during development., G2944013951, Integration strategies of GABAergic interneuron subtypes in the normal and dysfunctional neonatal cerebral cortex, Role of subplate neurosecretion in early cortical circuit formation, G6522567469
OpenAlex ID: W2256316452