Work

Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue

Year: 2016

Type: article

Abstract: This modular assembly approach to microfabricate functional cardiovascular tissue composites enables quantitative assessment of the effects of microarchitecture on cellular function. Cardiac and endothelial modules are micromolded separately, designed to direct cardiomyocyte alignment and anisotropic contraction or vascular network formation. Assembled cardiovascular tissue composites contract synchronously, facilitating the use of this tissue-engineering platform to study structure-function relationships in the heart.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.201500956

Authors: Benjamin W. Lee, Bohao Liu, Adam Pluchinsky, Nathan Kim, George Eng, Gordana Vunjak‐Novakovic

Institution: Columbia University

Language: English

Topic: Tissue Engineering and Regenerative Medicine

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Biomedical Imaging and Bioengineering