BridgesLab/CushingAcromegalyStudy: Cushing's and Acromegaly Dataset (Carr et al. Submission)
Year: 2014
Type: dataset
Abstract: This dataset is for the manuscript submission titled Glucocorticoid-Induced Metabolic Disturbances are Exacerbated in Obesity. This dataset includes all raw and calculated data and scripts used for generating figures and the statistical tests. Some key findings of this manuscript include: Obese Cushing's disease patients have worse NAFLD and insulin resistance than either obese or Cushingoid patients alone. A mouse model in which HFD-induced obese animals were exposed to dexamethasone had substantial insulin resistance, hyperglycemia and NAFLD. Glucocorticoids induce lipolysis and expression of the key gene Pnpla2 encoding for ATGL. In obese animals, glucocorticoids enhance the expression of ATGL, and have increased lipolysis.
Authors: Tran, Quynh, Bridges, Dave, Harvey, Innocence, Hochberg, Irit, Stephenson, Erin J, Barkan, Ariel R, Saltiel, Alan R, Chandler, William F
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W6931328736