Work

Animal models of substance abuse and addiction: implications for science, animal welfare, and society.

Year: 2010

Type: article

Abstract: Substance abuse and addiction are well recognized public health concerns, with 2 NIH institutes (the National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism) specifically targeting this societal problem. As such, this is an important area of research for which animal experiments play a critical role. This overview presents the importance of substance abuse and addiction in society; reviews the development and refinement of animal models that address crucial areas of biology, pathophysiology, clinical treatments, and drug screening for abuse liability; and discusses some of the unique veterinary, husbandry, and IACUC challenges associated with these models.

Source: PubMed Central

Authors: Wendy J Lynch, Katherine L Nicholson, Mario E Dance, Richard W Morgan, Patricia L Foley

Institution: University of Virginia

Language: English

Topic: Animal testing and alternatives

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse

Awards: The Behavioral Pharmacology of Phencyclidine, Rat Models of Alcohol Dependence for Evaluating Combined Medication Effects