Clinicopathological correlates of depression in early Alzheimer's disease in the NACC
Year: 2016
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Depression may be a prodrome to Alzheimer's disease (AD). We assessed whether AD neuropathology is associated with depression in mild cognitive impairment (MCI) and mild dementia (dAD). METHODS: All clinical and neuropathological data for this study came from the National Alzheimer's Coordinating Center (NACC). Healthy control (HC, n = 120), MCI (n = 77), and mild dAD (n = 93) patients who underwent brain autopsy were included. In regression models with Geriatric Depression Scale (GDS) as the outcome, neuritic plaque (NP) score or Braak Stages of neurofibrillary (NF) pathology were covariates. RESULTS: GDS was not associated with cognitive status, NP score, Braak Stages, or their interaction. In both models, a history of TIAs, depression within the last 2 years, current benzodiazepine use, and greater severity of neuropsychiatric symptoms were associated with greater depression. In the Braak Stages model, less education was another significant predictor. CONCLUSIONS: Depression in early AD appears to be independent of NP and NF pathology. Studies are needed to investigate other mechanisms that may be responsible for depression in MCI and dAD.
DOI: 10.1002/gps.4435
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Institute on Aging
Awards: UC Davis Alzheimer's Disease Core Center, Indiana Alzheimer Disease Center, University of Kentucky Alzheimer's Disease Core Center, Neurobiology of Alzheimer's Disease and Aging, Alzheimer's Disease Research Center, National Alzheimer's Coordinating Center, UCSD Alzheimer's Disease Research Center P50, Alzheimer's Disease Research Center, UCLA Alzheimer's Disease Research Center, Alzheimer's Disease Core Center, The Alzheimer's Disease Research Center at the University of California, Irvine, Oregon Alzheimer's Disease Center, Rush Alzheimer's Disease Core Center, Alzheimer's Disease Core Center, Alzheimer's Disease Research Center - Overall, Wisconsin Alzheimer's Disease Research Center, University of Kansas Alzheimer's Disease Core Centers, Alzheimer's Disease Research Center, Alzheimer Disease Research Center, Arizona Alzheimer's Disease Core Center, Johns Hopkins Alzheimer's Disease Research Center, Boston University Alzheimer's Disease Center, Alzheimer's Disease Research Center, Massachusetts Alzheimer's Disease Research Center, Alzheimer's Disease Core Center, Emory Alzheimer's Disease Center, Research Training in Age-Related Cognitive Disorders, New Approaches to Dementia Heterogeneity, Mayo Alzheimer's Disease Research Center
OpenAlex ID: W2260677129