An Imidazopyridinone and Further Metabolites from Streptomycetes [1]
Year: 2009
Type: article
Abstract: Screening and chromatographic analysis of the extracts from the terrestrial streptomycete GW5127 and from the marine Streptomyces sp. isolate B7967 yielded four new metabolites, i.e. 8-ethyl-6,11-dihydroxy-l1-methoxy-naphthacene-5,12-dione (la), 4-acetyl-1,3-dihydro-imidazo[4,5-c]pyridin-2-one (4a), 5-hydroxmethyl-4-hydroxy-2,4-dimethyl-2-cyclopentenone (6), and N-[2-(3'-hydroxy-4'-methoxyphenyl)-ethyl]-acetamide (5a), along with five known compounds, beta-rubromycin (2), rubromycin (3), 2-(3'-hydroxy-4'-methoxyphenyl)ethanol (5b), uracil, and N-acetyltyramine. The structures of the new compounds were deduced from high resolution mass, 1D and 2D NMR spectra and by comparison with related compounds from the literature. The antibiotic activity of the crude extracts was due to 2 and 3.
Source: Natural Product Communications
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2439338024