Микробный фактор, как парадокс критического состояния при абдоминальном сепсисе
Year: 2015
Type: article
Abstract: Article is devoted to detailing microbial factors in Gram-negative sepsis. Gram, including nosocomial sepsis is an important problem in clinical medicine. At physiological concentrations of endotoxin is essential stimulator of immune cells and myelopoiesis coagulation system that reflects consistency antiendotoxin natural systems. At generalization of Gram-negative inflammatory etiology, in response to the powerful effect of endotoxin on the endothelial cells and the immune response, there is a cascading release of biologically active substances and compensatory anti-inflammatory response by secretion/activation protein-receptor complexes and cytokines. Attempts to use the anti-endotoxin immunity in severe sepsis so far unsuccessfully. Prospects for improving the results of treatment of patients with sepsis may be connected with the development and implementation of anti-cytokine, anti-TLR, anti-DAMP therapy, as well as the possibility of interruption of nuclear transcription factor.
Authors: А. М. Карсанов, З О Карсанова, Ф Т Саламова
Language: Russian
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2261511681