Effects of Antidepressants on Cytokine Alterations in Serum and Depressive-like Behavior After Lipopolysaccharide Administration in Mice
Year: 2013
Type: dissertation
Abstract: Accumulating evidence suggests that inflammation may play a role in the pathophysiology of major depressive disorder (MDD).Antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), possess anti-inflammatory effects in vitro.Here, we examined the effects of SSRIs and SNRIs on lipopolysaccharide (LPS)-induced inflammation and depressive-like behavior in male mice.A single administration of LPS (0.5 mg/kg, i.p.) increased serum levels of the pro-inflammatory cytokine, tumor necrosis factor alpha (TNF) and the anti-inflammatory cytokine, interleukin-10 (IL-10) in mice.Pretreatment with SSRIs (fluoxetine and paroxetine), SNRIs (venlafaxine and duloxetine), or 5-hydroxytryptophan (5-HTP), a precursor of serotonin, attenuated LPS-induced increases in TNF, whereas it increased serum levels of IL-10, in mice treated with LPS.In the tail suspension test (TST), LPS increased the immobility time without affecting spontaneous locomotor activity, suggesting that LPS induced depressive-like behavior in mice.Treatment with fluoxetine (30 mg/kg) or paroxetine (10 mg/kg) significantly shortened LPS-induced increases of immobility time.These results suggested that antidepressants exert anti-inflammatory effects in vivo, and that the serotonergic system may partially mediate these effects.In addition, the anti-inflammatory effects of antidepressants may help alleviate the symptoms of LPS-induced depression in mice.
Language: English
Subfield: Biological Psychiatry
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2261897650