Work

An agonist antibody that blocks autoimmunity by inducing anti‐inflammatory macrophages

Year: 2015

Type: article

Abstract: We have devised a method of using intracellular combinatorial libraries to select antibodies that control cell fates. Many agonist antibodies have been selected with this method, and the process appears to be limited only by the availability of a phenotypic selection system. We demonstrate the utility of this approach to discover agonist antibodies that engage an unanticipated target and regulate macrophage polarization by selective induction of anti‐inflammatory M2 macrophages. This antibody was used therapeutically to block autoimmunity in a classic mouse model of spontaneous systemic lupus erythematosus.—Han, K. H., Gonzalez‐Quintial, R., Peng, Y., Baccala R., Theofilopoulos, A. N., Lerner, R. A. An agonist antibody that blocks autoimmunity by inducing anti‐inflammatory macrophages. FASEB J. 30, 738‐747 (2016). www.fasebj.org

Source: The FASEB Journal

DOI: 10.1096/fj.15-281329

Authors: Kyung Ho Han, Rosana Gonzalez‐Quintial, Yingjie Peng, Roberto Baccala, Argyrios N. Theofilopoulos, Richard A. Lerner

Institution: Scripps Research Institute

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases