Work

Characterization of the Rearranged tpr-met Oncogene Breakpoint

Year: 1987

Type: article

Abstract: We determined the nucleotide sequence of the rearranged trp-met genomic locus and the corresponding portions of the unrearranged tpr and met genomic fragments. The breakpoints occur at one end of a stretch of 21 A residues that follow an Alu repetitive sequence in the tpr locus and within a group of 3 A residues in the met proto-oncogene locus. We conclude that the fusion between the tpr locus on chromosome 1 and the met locus on chromosome 7 resulted from a recombination event.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.7.2.921

Authors: M Dean, M Park, G F Vande Woude

Institution: Frederick National Laboratory for Cancer Research

Language: English

Topic: Genomic variations and chromosomal abnormalities

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Public Health Service, National Cancer Institute