Work

Engaging Alkenyl Halides with Alkylsilicates via Photoredox Dual Catalysis

Year: 2016

Type: article

Abstract: Single-electron transmetalation via photoredox/nickel dual catalysis provides the opportunity for the construction of Csp(3)-Csp(2) bonds through the transfer of alkyl radicals under very mild reaction conditions. A general procedure for the cross-coupling of primary and secondary (bis-catecholato)alkylsilicates with alkenyl halides is presented. The developed method allows not only alkenyl bromides and iodides but also previously underexplored alkenyl chlorides to be employed.

Source: Organic Letters

DOI: 10.1021/acs.orglett.6b00024

Authors: Niki R. Patel, Christopher B. Kelly, Matthieu Jouffroy, Gary A. Molander

Institution: University of Pennsylvania

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: University of Pennsylvania, National Institute of General Medical Sciences