Work

A novel joint location-scale testing framework for improved detection of variants with main or interaction effects

Year: 2014

Type: preprint

Abstract: We propose a novel and easy-to-implement joint location-scale association testing procedure that can account for complex genetic architecture without explicitly modeling interaction effects, and is suitable for large-scale whole-genome scans and meta-analyses. We focus on Fisher's method and use it to combine evidence from the standard location test and the more recent scale test, and we describe its use for single-variant, gene-set and pathway association analyses.

Source: arXiv (Cornell University)

DOI: 10.48550/arxiv.1411.3690

Authors: Soave, David, Paterson, Andrew, Strug, Lisa, Sun, Lei

Institutions: University of Toronto, Hospital for Sick Children, Sickkids Research Institute

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: University of Toronto, Canadian Institutes of Health Research, Natural Sciences and Engineering Research Council of Canada

OpenAlex ID: W2263707705

Cites: 27

Cited by:

Related to: 10