Work

Synthetic Biomaterials from Metabolically Derived Synthons

Year: 2016

Type: review

Abstract: The utility of metabolic synthons as the building blocks for new biomaterials is based on the early application and success of hydroxy acid based polyesters as degradable sutures and controlled drug delivery matrices. The sheer number of potential monomers derived from the metabolome (e.g., lactic acid, dihydroxyacetone, glycerol, fumarate) gives rise to almost limitless biomaterial structural possibilities, functionality, and performance characteristics, as well as opportunities for the synthesis of new polymers. This review describes recent advances in new chemistries, as well as the inventive use of traditional chemistries, toward the design and synthesis of new polymers. Specific polymeric biomaterials can be prepared for use in varied medical applications (e.g., drug delivery, tissue engineering, wound repair, etc.) through judicious selection of the monomer and backbone linkage.

Source: Chemical Reviews

DOI: 10.1021/acs.chemrev.5b00465

Authors: Nicole G. Ricapito, Cynthia Ghobril, Heng Zhang, Mark W. Grinstaff, David Putnam

Institutions: Cornell University, Boston University

Language: English

Topic: biodegradable polymer synthesis and properties

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of Biomedical Imaging and Bioengineering

Awards: Efficacy and Safety of a Novel, Implantable Drug-eluting Film in Sarcoma, Translational Research in Biomaterials