Work

miRNA Deregulation in Cancer Cells and the Tumor Microenvironment

Year: 2016

Type: article

Abstract: UNLABELLED: miRNAs are a key component of the noncoding RNA family. The underlying mechanisms involved in the interplay between the tumor microenvironment and cancer cells involve highly dynamic factors such as hypoxia and cell types such as cancer-associated fibroblasts and macrophages. Although miRNA levels are known to be altered in cancer cells, recent evidence suggests a critical role for the tumor microenvironment in regulating miRNA biogenesis, methylation, and transcriptional changes. Here, we discuss the complex protumorigenic symbiotic role between tumor cells, the tumor microenvironment, and miRNA deregulation. SIGNIFICANCE: miRNAs play a central role in cell signaling and homeostasis. In this article, we provide insights into the regulatory mechanisms involved in the deregulation of miRNAs in cancer cells and the tumor microenvironment and discuss therapeutic intervention strategies to overcome this deregulation.

Source: Cancer Discovery

DOI: 10.1158/2159-8290.cd-15-0893

Authors: Rajesha Rupaimoole, George A. Calin, Gabriel Lopez-Berestein, Anil K. Sood

Institution: The University of Texas MD Anderson Cancer Center

Language: English

Topic: MicroRNA in disease regulation

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, University of Texas MD Anderson Cancer Center, National Cancer Institute, National Center for Advancing Translational Sciences