Work

Vstat120 modulates inhibits oncolytic viral therapy induced angiogenesis and innate pro-inflamatory response, augmenting oncolytic viral thereapy of glioblastom multiforme

Year: 2011

Type: article

Abstract: Glioblastoma multiform is one of the deadliest cancers known and represents approximately 40% of all primary brain tumors diagnosed.A major histopathological hallmark of these tumors is increased vascularity and micro-vascular proliferation.Work recently completed by our lab showed increased micro-vascular density (MVD) following oncolytic virus (OV) therapy.To this end we created a novel armed OV termed RAMBO (Rapid Anti-angiogenesis Mediated By Oncolytic virus) that contains the transgene econding Vasculostatin (Vstat120).Vstat120 is the extracellular fragment of

Source: OhioLink ETD Center (Ohio Library and Information Network)

Author: Jayson Hardcastle

Institution: The Ohio State University

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2264607299

FWCI:

Cites: 236

Cited by:

Related to: 10