Year: 2015
Type: article
Abstract: Transplantation is a cure for end-stage organ failure but, in the absence of pharmacological immunosuppression, allogeneic organs are acutely rejected. Such rejection invariably results in allosensitization and accelerated rejection of secondary donor-matched grafts. Transplantation tolerance can be induced in animals and a subset of humans, and enables long-term acceptance of allografts without maintenance immunosuppression. However, graft rejection can occur long after a state of transplantation tolerance has been acquired. When such an allograft is rejected, it has been assumed that the same rules of allosensitization apply as to non-tolerant hosts and that immunological tolerance is permanently lost. Using a mouse model of cardiac transplantation, we show that when Listeria monocytogenes infection precipitates acute rejection, thus abrogating transplantation tolerance, the donor-specific tolerant state re-emerges, allowing spontaneous acceptance of a donor-matched second transplant. These data demonstrate a setting in which the memory of allograft tolerance dominates over the memory of transplant rejection.
Source: Nature Communications
DOI: 10.1038/ncomms8566
Authors: Michelle L. Miller, Melvin D. Daniels, Tongmin Wang, Jianjun Chen, James Young, Jing Xu, Ying Wang, Dengping Yin, Vinh Vu, Aliya N. Husain, Maria-Luisa Alegre, Anita S. Chong
Institutions: University of Chicago, Chicago State University
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $6,990
Awards: Mechanistic studies on Listeria infection and inhibition of allograft tolerance, G1379710659, G1459655681, G2340152788, G265583921, Cardiovascular Pathophysiology and Biochemisty Training Program, Reduced avidity endogenous graft-specific T cells in transplantation tolerance, G4267166770, G4795955448, G529657565, G6212863132, G845613041, Infections and the Stability of Transplantation Tolerance, G972191158
OpenAlex ID: W2264847896