Work

Injury, inflammation and the emergence of human‐specific genes

Year: 2016

Type: article

Abstract: In light of the central role of inflammation in normal wound repair and regeneration, we hypothesize that the preponderance of human-specific genes expressed in human inflammatory cells is commensurate with the genetic versatility of inflammatory response and the emergence of injuries associated with uniquely hominid behaviors, like a bipedal posture and the use of tools, weapons and fire. The hypothesis underscores the need to study human-specific signaling pathways in experimental models of injury and infers that a selection of human-specific genes, driven in part by the response to injury, may have facilitated the emergence of multifunctional genes expressed in other tissues.

Source: Wound Repair and Regeneration

DOI: 10.1111/wrr.12422

Authors: Andrew Baird, Todd Costantini, Raul Coimbra, Brian P. Eliceiri

Institutions: UC San Diego Health System, University of California San Diego

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,750