Análise das alterações patológicas decorrentes do envelhecimento em indivíduos com cisticercose.
Year: 2007
Type: dissertation
Study design: Observational Study
Abstract: The immunosenescence, a peculiarity of the aging process, increases the susceptible of elderly individuals to the neoplasias, infections and parasitosis, among them, to the cysticercosis. The aim of this study was to characterize epidemiological characteristics the elderly individuals with cysticercosis, and to analyze, through morphometric methods, the general pathological processes in the heart and in the encephalon decurrent of the parasitosis, related to the aging. Were reviewed 3680 autopsies protocols accomplished at School Hospital of the Triangulo Mineiro Federal University, in the period from 1970 at 2007. Two groups were formed: elderly with cysticercosis (n=20), and non elderly with cysticercosis (n=21). We used the Computadorized System KS300 (Zeiss) for morphometry. The leucocyte number was counted in absolute value by fields, in the stained slides by hematoxylin-eosin. In the fibrosis quantification, were used stained slides by picro-sirius analyzed under polarized filter. There was occurrence of 26.7% of elderly in the group with cysticercosis. In the elderly group, 80% presented neurocysticercosis and 20% cardiac cysticercosis. There was prevalence of the Vesicular Stage and Colloidal Vesicular Stage (75%) among the elderly. The cause of death neoplasic attacked 40% and the cardiovascular 35% of the elderly with cysticercosis. The most of the elderly (75%) attacked by the parasitosis was undernourished. The individuals with cysticercosis, significantly, decrease of the inflammatory infiltrated and increase of the fibrosis with elapsing of the age. Among the elderly group, the female gender presented more cardiac and encephalic inflammation and cardiac fibrosis than male gender. Therefore we ended that, a high occurrence of elderly exist in the group with cysticercosis, and the epidemic characteristics of the elderly are similar the characteristics of the non elderly attacked by the parasitosis. Probably being added the immunological alterations happened during the aging, the cysticercosis contributes to formation of a favorable condition for the neoplasias development in elderly individuals with cysticercosis.%%%%A imunosenescencia, uma peculiaridade do processo de envelhecimento, aumenta a susceptibilidade dos individuos idosos as neoplasias, as infeccoes e as parasitoses, entre elas, a cisticercose. Os objetivos desse trabalho foram caracterizar o perfil epidemiologico dos individuos idosos com cisticercose, e analisar, atraves de metodos morfometricos, os processos patologicos gerais no coracao e no encefalo decorrentes da parasitose, frente ao envelhecimento. Foram revistos 3680 protocolos de autopsias realizadas no Hospital Escola da Universidade Federal do Triângulo Mineiro, no periodo de 1970 a 2007. Dois grupos foram formados: idosos com cisticercose (n=20), e nao idosos com cisticercose (n=55). Na morfometria foi utilizado o sistema computadorizado KS300 (Zeiss). O numero de leucocitos foi contado em valor absoluto por campos, nas lâminas coradas pela hematoxilina-eosina. Para a quantificacao…
Author: Camila Lourencini Cavellani
Language: Portuguese
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2266455600