Repeated Foot Pad Electrical Stimulation Facilitate Electrical Kindling in Rats
Year: 2014
Type: article
Abstract: Background and purpose: Kindling is an animal model of epilepsy induced by repeated stimulation of the brain. The amygdala has been the focus of interest due to large part to its role in epilepsy induction and in fear conditioning in both human and rats. The purpose of the present study was to evaluate whether low electrical stimulation of foot pad of rats during fear can facilitate amygdala electrical kindling susceptibility. Material and methods: 32 Wistar male rats trained for the two way active avoidance learning in the shuttle box on the basis of escape response were divided into fast and slow learning animals and then each group was randomly assigned to two groups. Test groups (n= 10) received conditional and unconditional stimulus and control groups (n= 8) received conditional stimulus for ten days. The rats were kindled by electrical stimulation of basolateral amygdala and the seizure parameters were noted. The data were analyzed using one way ANOVA and Tukey’s test. Results: The results of the present study demonstrate that repeated electrical stimulation of slow learning animals during fear condition facilitates kindling induction. Conclusion: It seems that repeated electrical stimulation after fearing in rats that have impairments in performance of shuttle box conditioning increase the susceptibility to electrical kindling.
Authors: Mohammad Reza Palizvan, Shadi Khademi
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2266643523