Year: 2012
Type: dissertation
Abstract: Fibromyalgia (FM) is a non-inflammatory pain syndrome characterized by generalized myalgia and localized point tenderness.Associated symptoms typically include sleep disturbance, fatigue, anxiety, morning stiffuess, and depression.The incidence of fibromyalgia is estimated to be 2% in the general community and is increasing among perimenopausal and menopausal women.The etiology of fibromyalgia is not known.More recent research has focused on neuroendocrine and central nervous system involvement.Proposed etiologies include: primary adrenal insufficiency as a result of an altered hypothalamic-pituitary-adrenal (HPA) axis; altered regulation ofthe sympathetic nervous system; hypoactive corticotropin-releasing hormone (CRR) neuron; and changes in the central processing of pain at the spinal level.The diagnosis of fibromyalgia is difficult to make because of symptom variability and the coexistence of other conditions with fibromyalgia.The unknown etiology and pathogenesis make fibromyalgia difficult to treat.Antidepressants in combination with exercise appear to be the most effective therapy.The management goals for fibromyalgia are to control depression, improve sleep disturbance, and reduce pain.
Author: Stacey K. Wright
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2266810732