Cognitive Training Changes Hippocampal Function in Mild Cognitive Impairment: A Pilot Study
Year: 2011
Type: article
Study design: Clinical Trial
Abstract: A randomized pilot experiment examined the neural substrates of response to cognitive training in participants with mild cognitive impairment (MCI). Participants performed exercises previously demonstrated to improve verbal memory and an active control group performed other computer activities. An auditory-verbal fMRI task was conducted before and after the two-month training program. Verbal memory scores improved significantly and left hippocampal activation increased significantly in the experimental group (gains in 5 of 6 participants) relative to the control group (reductions in all 6 participants). Results suggest that the hippocampus in MCI may retain sufficient neuroplasticity to benefit from cognitive training.
Source: Journal of Alzheimer s Disease
Authors: Allyson C. Rosen, Lisa Sugiura, Joel H. Kramer, Susan Whitfield-Gabrieli, John D. Gabrieli
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: G1322919651, G2153143919, G2182814872, G3585335293, G388319536, FMRI and TMS Analysis of Frontal Lobes in Aging, G481380072, FUNCTIONAL MRI ANALYSIS OF MEMORY IN AGING, Center for Advanced Magnetic Resonance Technology at Stanford, MEMORY AND MENTAL HEALTH IN AGING, Anatomic, Physiologic, and Cognitive Pathology of AD, Mechanism of mitotic exit in budding yeast, AGING AND INHIBITORY BEHAVIOR: AN FMRI STUDY, Memory and Mental Health in Aging, FMRI ANALYSIS OF DECLARATIVE MEMORY, New Approaches to Dementia Heterogeneity
OpenAlex ID: W1954736548