Work

Perspective: Molecular Identity of the Outwardly Rectifying, Swelling-activated Anion Channel: Time to Reevaluate pICln

Year: 1998

Type: review

Abstract: Cells respond to swelling by activating anion and cation channels that allow the passive loss of inorganic ions and organic solutes. Net solute efflux accompanied by osmotically obliged water functions to return cell volume towards its original value, a process termed regulatory volume decrease. An

Source: The Journal of General Physiology

DOI: 10.1085/jgp.111.5.617

Author: Kevin Strange

Institution: Vanderbilt University Medical Center

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke

Awards: G2672515767, G3673905138, CELLULAR AND MOLECULAR BASIS OF BRAIN VOLUME REGULATION, Structure-function analysis of the volume-regulated anion channel VRAC using novel LRRC8 chimeras