Work

A single amino acid change A91V in perforin: a novel, frequent predisposing factor to childhood acute lymphoblastic leukemia?

Year: 2005

Type: letter

Abstract: We screened 100 children with acute lymphoblastic leukemia (ALL) to assess the incidence of single amino acid change A91V in perforin. Heterozygous A91V was found in 12/100 patients and 5/127 controls (OR, 3.4; 95%CI: 1.15-9.95; p=0.014). A91V is a novel and frequent predisposing factor for childhood ALL.

Source: PubMed

Authors: Alessandra Santoro, Sonia Cannella, Antonino Trizzino, Luca Lo Nigro, Giovanni Corsello, Maurizio Aricò

Language: English

Topic: Acute Lymphoblastic Leukemia research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Ministero della Salute, Associazione Italiana per la Ricerca sul Cancro

OpenAlex ID: W2268797426

Cites: 6

Cited by: 67

Related to: 10