Work

A Linkage Map of the Rat Genome Derived from Three F2 Crosses

Year: 1997

Type: preprint

Abstract: We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism. F2 populations from WKY x S (n = 159), BN x S (n = 91), and BN x GK (n = 139) were selected and genotyped for combinations of microsatellite markers. The loci define 21 linkage groups corresponding to the 20 rat autosomal chromosomes and the X chromosome. The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes.

Source: Genome Research

DOI: 10.1101/gr.7.5.434

Authors: Marie Thérèse Bihoreau, Dominique Gauguier, Norihiro Kato, Gina Hyne, Klaus Lindpaintner, John P. Rapp, Michael R. James, G. Mark Lathrop

Institutions: University of Toledo Medical Center, Brigham and Women's Hospital, Centre for Human Genetics, Harvard University, University of Oxford

Language: English

Topic: Genetic Mapping and Diversity in Plants and Animals

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Wellcome Trust, European Commission

OpenAlex ID: W2269233083

Cites: 22

Cited by: 141

Related to: 10