Work

Revisiting vitamin C in cancer therapy: Is “C” for cure, or just wishful thinking?

Year: 2015

Type: other

Abstract: We devoted this short piece to highlight one recent article published in Science, which revisited the anti-cancer efficacy of high-dose vitamin C. Using isogeneic KRAS- and BRAF-mutated colorectal cell lines, the authors were able to demonstrate selective anti-tumor effects among the KRAS- and BRAF-mutated cells in culture and in ex-planted animal models treated with high-dose vitamin C. Their elegant and in-depth studies unequivocally tied the tumoricidal effect to the heightened sensitivity of the mutant cells due to the increased vitamin C uptake, leading to lethal accumulation of reactive oxygen species (ROS). This report will certainly rekindle enthusiasm in revisiting the case of vitamin C, pushing for more definitive cancer therapy trials.

Source: Genes & Diseases

DOI: 10.1016/j.gendis.2015.12.001

Authors: Fei Li, Lin Zhang, Shou-Ching Tang

Institutions: UPMC Hillman Cancer Center, Augusta University, Tianjin Medical University Cancer Institute and Hospital

Language: English

Topic: Vitamin C and Antioxidants Research

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,500