Work

Expanding the antimalarial toolkit: Targeting host–parasite interactions

Year: 2016

Type: review

Abstract: Recent successes in malaria control are threatened by drug-resistant Plasmodium parasites and insecticide-resistant Anopheles mosquitoes, and first generation vaccines offer only partial protection. New research approaches have highlighted host as well as parasite molecules or pathways that could be targeted for interventions. In this study, we discuss host-parasite interactions at the different stages of the Plasmodium life cycle within the mammalian host and the potential for therapeutics that prevent parasite migration, invasion, intracellular growth, or egress from host cells, as well as parasite-induced pathology.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20151677

Authors: Jean Langhorne, Patrick E. Duffy

Institutions: National Institute for Medical Research, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Wellcome Trust, Cancer Research UK, Medical Research Council, National Institute of Allergy and Infectious Diseases