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Practical Protocols for the Preparation of Highly Enantioenriched Silyl Ethers of (R)-3-Hydroxypentan-2-one, Building Blocks for the Synthesis of Macrolide Antibiotics

Year: 2015

Type: article

Abstract: Methacrolein is transformed in three steps to ( R )-3- tert -butyldiphenylsilyloxypentan-2-one or ( R )-3- tert -butyldimethylsilyloxypentan-2-one, compounds which serve as building blocks for the construction of macrolide antibiotics. The route is practical, highly enantioselective, and easily scaled.

Source: Synlett

DOI: 10.1055/s-0035-1560972

Authors: Andrew Myers, Ian Seiple, Daniel Hog

Institution: Harvard University

Language: English

Topic: Organic Chemistry Synthesis Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Harvard University, Deutsche Forschungsgemeinschaft, National Institutes of Health

OpenAlex ID: W2270429788

FWCI: 0.458

Cites:

Cited by: 5

Related to: 10