Work

ESR1 Mutations in Breast Cancer: Proof-of-Concept Challenges Clinical Action

Year: 2015

Type: article

Abstract: Wang and colleagues demonstrate that digital droplet PCR (ddPCR) identified ESR1 mutations in 7% of primary breast cancers. ESR1 mutations were also readily detected in metastatic tissues and circulating tumor DNA in the blood. These results suggest that ddPCR may be amendable for monitoring tumor burden, and to predict relapse. See related article by Wang et al., p. 1130.

Source: Clinical Cancer Research

DOI: 10.1158/1078-0432.ccr-15-2549

Authors: Guowei Gu, Suzanne A.W. Fuqua

Institutions: Baylor College of Medicine, Dan L Duncan Comprehensive Cancer Center

Language: English

Topic: Cancer Genomics and Diagnostics

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute