Year: 2016
Type: review
Abstract: Inositol 1,4,5-trisphosphate receptors (IP3 Rs) are expressed in nearly all animal cells, where they mediate the release of Ca(2+) from intracellular stores. The complex spatial and temporal organization of the ensuing intracellular Ca(2+) signals allows selective regulation of diverse physiological responses. Interactions of IP3 Rs with other proteins contribute to the specificity and speed of Ca(2+) signalling pathways, and to their capacity to integrate information from other signalling pathways. In this review, we provide a comprehensive survey of the proteins proposed to interact with IP3 Rs and the functional effects that these interactions produce. Interacting proteins can determine the activity of IP3 Rs, facilitate their regulation by multiple signalling pathways and direct the Ca(2+) that they release to specific targets. We suggest that IP3 Rs function as signalling hubs through which diverse inputs are processed and then emerge as cytosolic Ca(2+) signals.
Source: The Journal of Physiology
DOI: 10.1113/jp271139
Authors: David L. Prole, Colin W. Taylor
Institution: University of Cambridge
Language: English
Subfield: Physiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,568
OpenAlex ID: W2271367358