당뇨병환자에서 정맥내 Insulin 투여에 따른 Insulin 길항 Hormone 의 변동
Year: 1987
Type: article
Abstract: In order to observe the changes of counterregulatory hormones after insulin induced hypoglycemia in IDDM, NIDDM and Vacor induced diabetes. Levels of blood glucose and counterregulatory hormones such as glucagon, growth hormone and cortisol of normal controls and the diabetes in overnight fasting state were measured before and after insulin infusion. The results were as follows; 1) In normal controls after insulin infusion plasma glucose concentration decreased abruptly to reach nadirs in 20 minutes (23.3±8.9mg/dl) while glucagon secretion increased twofold above baseline in 40 minutes (70.5±28.9 to 148.5±19.9, p<0.005). 2) In IDDM and NIDDM after insulin infusion plasma glucose concentration decreased slowly to reach nadirs in 50 minutes, however, in Vacor diabetes to reach in 120 minutes, Glucagon response in IDDM groups was depressed compared with other two diabetic groups. 3) The pattern of plasma growth hormone and cortisol secretion in IDDM and NIDDM was similar to normal controls, but in Vacor diabetes responses of growth hormone and cortisol were significantly decreased compared with other two diabetic groups. These results suggest that glucose recovery from insulin induced hypoglycemia in the diabetes was retarded compared with normal controls, it may be probably due to decreased response of glucagon secretion to hypoglycemia.
Language: Korean
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $500
OpenAlex ID: W2271534741