Work

Convergent BCL6 and lncRNA promoters demarcate the major breakpoint region for BCL6 translocations

Year: 2015

Type: article

Abstract: To the editor: We recently published a study showing that BCL6 translocations occur at distinct sequence motifs within intron 1 of the BCL6 gene that are recognized and deaminated by activation-induced cytidine deaminase (AID).[1][1] It has been unclear, however, why these breakpoints cluster in an

Source: Blood

DOI: 10.1182/blood-2015-07-657999

Authors: Z. Lu, N. R. Pannunzio, H. A. Greisman, D. Casero, C. Parekh, M. R. Lieber

Institutions: University of Southern California, USC Norris Comprehensive Cancer Center, University of California, Los Angeles, Children's Hospital of Los Angeles

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences