Continued Slow Decay of the Residual Plasma Viremia Level in HIV-1–Infected Adults Receiving Long-term Antiretroviral Therapy
Year: 2015
Type: article
Abstract: UNLABELLED: We measured plasma human immunodeficiency virus type 1 (HIV-1) RNA levels by means of single-copy assay in 334 participants receiving virologically suppressive antiretroviral therapy (ART). A residual viremia load of ≥1 copy/mL after 4 years of ART was predicted by a higher pre-ART HIV-1 RNA level, higher CD8(+) T-cell count during treatment, and a lower ratio of CD4+ T cells to CD8+ T cells during treatment but not by initial ART regimen. In a longitudinal subset of 64 individuals, continued decay of the plasma HIV-1 RNA level was observed, with an average annual decrease of 6% and an estimated half-life of 11.5 years. In contrast to prior reports, the persistent viremia level continues to slowly decline during years 4-12 of suppressive ART. CLINICAL TRIALS REGISTRATION: NCT00001137.
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Awards: Units for HIV/AIDS Clinical Trials Networks, New York University HIV/AIDS Clinical Trial Unit, Stanford AIDS Clinical Trials Unit, Emory HIV/AIDS Clinical Trials Unit, G16708505, G1811910189, G185513119, Vanderbilt HIV Clinical Trials Unit, University of North Carolina AIDS Clinical Trials Unit (UNC ACTU), UNIVERSITY OF SOUTHERN CALIFORNIA CLINICAL TRIALS UNIT, Cornell Clinical Trials Unit, UCLA Clinical and Translational Science Institute, G336435875, G3420175137, AIDS Clinical Trials Group Network, Alabama-Clinical Trials Unit, G3706441460, STATISTICAL AND DATA MANAGEMENT CENTER, G3873853564, North Carolina Translational & Clinical Sciences Institute (NC TraCS), Northwestern University Clinical Trial Unit, Case Clinical Trials Unit, Stanford AIDS Clinical Trials Unit, University of Pittsburgh Clinical Trials Unit, Integrated University of Puerto Rico Clinical Trials Unit, New York University HIV/AIDS Clinical Trial Unit, ADULT ACTG CENTRAL GROUP, Seattle Vaccine Trials Unit, San Francisco Vaccine and Prevention Unit, UCSD Department of Medicine HIV/AIDS Clinical Trials Unit, Colorado Clinical and Translational Sciences Institute, Atlanta Clinical and Translational Science Institute (ACTSI) Renewal, Case AIDS Clinical Trials Unit, UNIVERSITY OF SOUTHERN CALIFORNIA CLINICAL TRIALS UNIT, Partners Healthcare Systems/Harvard Medical School/Boston Medical Center AIDS CTU, University of Puerto Rico Clinical Trials Unit, The University of Rochester's Clinical and Translational Science Institute, Partners Healthcare Systems/Harvard Medical School/Boston Medical Center AIDS CTU, Clinical and Translational Science Center, Laboratory Center (LC): Microbicide Trials Network, The Vanderbilt Institute for Clinical and Translational Research (VICTR), G9000162062, UCSD Collaborative Clinical Trials Unit, University of Pennsylvania HIV Clinical Trials Unit, Weill Cornell Medicine - Rutgers New Jersey Medical School Clinical Trials Unit, Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections, Emory-CDC CTU, Chicago Clinical Trials Unit, HIV Neurobehavioral Research Center, AIDS Clinical Trial Group Laboratory Center, Center for AIDS Research at Emory University, Statistical and Data Management Center (SDMC), Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACTG), Penn Center for AIDS Research, The University of North Carolina Center for AIDS Research, Pitt-Ohio State Clinical Trials Unit, University of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit, San Francisco Bay Clinical Trials Unit (CTU), Seattle Clinical Trials Unit, Vanderbilt HIV Clinical Trials Unit (CTU), Boston HIV CTU, University of Rochester HIV/AIDS Clinical Trials Unit, A-Z Clinical Trials Unit
OpenAlex ID: W2272142554