Work

Involvement of endocannabinoid mechanisms in the antinociceptive effect of N2O in mice

Year: 2012

Type: other

Abstract: Nitrous oxide (N 2 O) and cannabinoid (CB) drugs both modulate pain and anxiety by interacting with multiple different systems, including the endogenous opioids, GABA and glutamatergic synaptic activity, nitric oxide(NO) and K + "leak" channels.♦ N 2 O-induced antinociception is only partly antagonized by opioid receptor blockers. ♦The aim of the work is to determine whether N 2 O might owe part of its antinociceptive effect to endocannabinoid mechanisms, which are also known to be involved in antinociception.

Source: Research Exchange (Washington State University)

Authors: Yangmiao Zhang, Yao Zhang, Linda K. Vaughn, Sabrina N. Nelson-Brown, Mengwei Liu, Raymond M. Quock

Language: English

Topic: Cannabis and Cannabinoid Research

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2273337128

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